Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models. Ari C, Murdun C, Goldhagen C, Koutnik AP, Bharwani SR, Diamond DM, Kindy M, D''Agostino DP, Kovacs Z.Genetic variants for personalised management of very low carbohydrate ketogenic diets. Aronica L, Volek J, Poff A, D''agostino DP.Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease. Norwitz NG, Winwood R, Stubbs BJ, D''Agostino DP, Barnes PJ.Ketone Bodies Impact on Hypoxic CO Retention Protocol During Exercise. Prins PJ, Buxton JD, McClure TS, D''Agostino DP, Ault DL, Welton GL, Jones DW, Atwell AD, Slack MA, Slack ML, Williams CE, Blanchflower ME, Kannel KK, Faulkner MN, Szmaciasz HL, Croll SM, Stanforth LM, Harris TD, Gwaltney HC, Koutnik AP. Ketone Supplementation: Meeting the Needs of the Brain in an Energy Crisis. Poff AM, Moss S, Soliven M, D''Agostino DP.Enhancement of Ketone Supplements-Evoked Effect on Absence Epileptic Activity by Co-Administration of Uridine in Wistar Albino Glaxo Rijswijk Rats. Brunner B, Rauch E, Ari C, D''Agostino DP, Kovács Z.Journal of applied physiology (Bethesda, Md. Exogenous ketone salts inhibit superoxide production in the rat caudal solitary complex during exposure to normobaric and hyperbaric hyperoxia. Hinojo CM, Ciarlone GE, D''Agostino DP, Dean JB.Systematic Review - Neuroprotection of ketosis in acute injury of the mammalian central nervous system: A meta-analysis. Gambardella I, Ascione R, D''Agostino DP, Ari C, Worku B, Tranbaugh RF, Ivascu N, Villena-Vargas J, Girardi LN.Regulatory, integrative and comparative physiology. Exogenous ketone ester delays CNS oxygen toxicity without impairing cognitive and motor performance in male Sprague-Dawley rats. Stavitzski NM, Landon CS, Hinojo CM, Poff AM, Rogers CQ, D''Agostino DP, Dean JB.Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats. Brunner B, Ari C, D''Agostino DP, Kovács Z.Assistant Professor (American Physiology Society, 1999 - Present).Assistant Professor (Society for Neuroscience, 2004 - Present).Assistant Professor (Aerospace Medicine, 2005 - Present).Assistant Professor (Undersea and Hyperbaric Medicine Society, 2005 - Present).Assistant Professor (Microscopy and Microanalysis, 2010 - Present).Assistant Professor (American Association for Cancer Research, 2014 - Present).Our laboratory is also interested in space research, including analog research on NASA's Extreme Environment Mission Operation (NEEMO 22 and NEEMO 23), which allows us to study environmental medicine and methods to enhance safety, performance and physiological resilience in astronauts and aquanauts. Our USF and collaborative research is supported by federal agencies (DOD, ONR, NAVSEA, NIH) industry partners, foundations (501c3) and contributions to our lab from generous donors to USF Nonprofit Foundation (501c3). Our laboratory uses in vivo and in vitro techniques to understand the physiological, cellular, molecular and epigenetic mechanism of therapies. The primary focus of our laboratory is developing and testing metabolic-based therapies, including dietary therapies, nutritional supplements and a variety of metabolic-based drugs.Allergy, Immunology & Infectious Disease."Educating future scientists and clinicians on metabolism-based research and therapies to advance the treatment and prevention of disease" Interdisciplinary and Emerging Signature Programs
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